The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes
Identifieur interne : 000050 ( France/Analysis ); précédent : 000049; suivant : 000051The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes
Auteurs : Svatava Lagronova-Churava [République tchèque] ; Frantisek Spoutil [République tchèque] ; Simona Vojtechova [République tchèque] ; Herve Lesot [France] ; Miroslav Peterka [République tchèque] ; Ophir D. Klein [États-Unis] ; Renata Peterkova [République tchèque]Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2013-07.
English descriptors
- KwdEn :
- Adult mice, Anterior part, Anterior portion, Anteroconid, Apoptosis, Apoptotic, Biol, Biol peterkova, Body weight, Cheek region, Cobourne, Craniofac genet, Cusp, Cusp pattern, Czech, Czech republic, Dental epithelium, Dental measurements, Dentition, Diastema, Embryo, Enamel, Enamel knot, Enamel organ, Epithelium, Evol, Experimental medicine, Expression domains, Histological, Histological sections, Horizontal direction, Incisor, Jernvall, Klein, Larger size, Leica, Leica dmlb microscope, Leica microsystems gmbh, Lesot, Lower apoptosis, Lower molar, Mandible, Mitosis, Mitotic, Mitotic cells, Molar, Morphogenesis, Morphometric, Morphometric analysis, Mouse, Mouse embryos, Mouse molar morphogenesis, Mouse odontogenesis, Mutant, Mutant mice, Odontogenesis, Ohazama, Peterka, Peterkova, Posteriorly, Postnatal, Premolar, Prenatal, Prenatal stages, Present data, Primordium, Prochazka, Quadrant, Revitalization, Ruch, Rudiment, Rudimentary buds, Rudimentary tooth primordia, Rudiments, Scale bars, Sonic hedgehog, Spatial distribution, Sprouty, Sprouty genes, Sprouty mutants, Spry2, Spry2 mutants, Spry4, Spry4 mutants, Supernumerary, Supernumerary teeth, Supernumerary tooth, Supernumerary tooth development, Supernumerary tooth formation, Supernumerary tooth germs, Tooth, Tooth development, Tooth primordia, Tooth primordium, Total length, Viriot, Vonesch, Zool.
- Teeft :
- Adult mice, Anterior part, Anterior portion, Anteroconid, Apoptosis, Apoptotic, Biol, Biol peterkova, Body weight, Cheek region, Cobourne, Craniofac genet, Cusp, Cusp pattern, Czech, Czech republic, Dental epithelium, Dental measurements, Dentition, Diastema, Embryo, Enamel, Enamel knot, Enamel organ, Epithelium, Evol, Experimental medicine, Expression domains, Histological, Histological sections, Horizontal direction, Incisor, Jernvall, Klein, Larger size, Leica, Leica dmlb microscope, Leica microsystems gmbh, Lesot, Lower apoptosis, Lower molar, Mandible, Mitosis, Mitotic, Mitotic cells, Molar, Morphogenesis, Morphometric, Morphometric analysis, Mouse, Mouse embryos, Mouse molar morphogenesis, Mouse odontogenesis, Mutant, Mutant mice, Odontogenesis, Ohazama, Peterka, Peterkova, Posteriorly, Postnatal, Premolar, Prenatal, Prenatal stages, Present data, Primordium, Prochazka, Quadrant, Revitalization, Ruch, Rudiment, Rudimentary buds, Rudimentary tooth primordia, Rudiments, Scale bars, Sonic hedgehog, Spatial distribution, Sprouty, Sprouty genes, Sprouty mutants, Spry2, Spry2 mutants, Spry4, Spry4 mutants, Supernumerary, Supernumerary teeth, Supernumerary tooth, Supernumerary tooth development, Supernumerary tooth formation, Supernumerary tooth germs, Tooth, Tooth development, Tooth primordia, Tooth primordium, Total length, Viriot, Vonesch, Zool.
Abstract
In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2−/− embryos. Apoptosis was also decreased in both rudiments in Spry4−/− embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2−/− mice, a high number of Spry4−/− supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jez.b.22502
Affiliations:
- France, République tchèque, États-Unis
- Alsace (région administrative), Bohême centrale, Californie, Grand Est
- Prague, Strasbourg
- Université de Strasbourg
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Klein</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Teratology, Institute of Experimental Medicine AS CR, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</title><title level="j" type="alt">JOURNAL OF EXPERIMENTAL ZOOLOGY PART B: MOLECULAR AND DEVELOPMENTAL EVOLUTION</title><idno type="ISSN">1552-5007</idno><idno type="eISSN">1552-5015</idno><imprint><biblScope unit="vol">320</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="307">307</biblScope><biblScope unit="page" to="320">320</biblScope><biblScope unit="page-count">14</biblScope><date type="published" when="2013-07">2013-07</date></imprint><idno type="ISSN">1552-5007</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-5007</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult mice</term><term>Anterior part</term><term>Anterior portion</term><term>Anteroconid</term><term>Apoptosis</term><term>Apoptotic</term><term>Biol</term><term>Biol peterkova</term><term>Body weight</term><term>Cheek region</term><term>Cobourne</term><term>Craniofac genet</term><term>Cusp</term><term>Cusp pattern</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dental measurements</term><term>Dentition</term><term>Diastema</term><term>Embryo</term><term>Enamel</term><term>Enamel knot</term><term>Enamel organ</term><term>Epithelium</term><term>Evol</term><term>Experimental medicine</term><term>Expression domains</term><term>Histological</term><term>Histological sections</term><term>Horizontal direction</term><term>Incisor</term><term>Jernvall</term><term>Klein</term><term>Larger size</term><term>Leica</term><term>Leica dmlb microscope</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower apoptosis</term><term>Lower molar</term><term>Mandible</term><term>Mitosis</term><term>Mitotic</term><term>Mitotic cells</term><term>Molar</term><term>Morphogenesis</term><term>Morphometric</term><term>Morphometric analysis</term><term>Mouse</term><term>Mouse embryos</term><term>Mouse molar morphogenesis</term><term>Mouse odontogenesis</term><term>Mutant</term><term>Mutant mice</term><term>Odontogenesis</term><term>Ohazama</term><term>Peterka</term><term>Peterkova</term><term>Posteriorly</term><term>Postnatal</term><term>Premolar</term><term>Prenatal</term><term>Prenatal stages</term><term>Present data</term><term>Primordium</term><term>Prochazka</term><term>Quadrant</term><term>Revitalization</term><term>Ruch</term><term>Rudiment</term><term>Rudimentary buds</term><term>Rudimentary tooth primordia</term><term>Rudiments</term><term>Scale bars</term><term>Sonic hedgehog</term><term>Spatial distribution</term><term>Sprouty</term><term>Sprouty genes</term><term>Sprouty mutants</term><term>Spry2</term><term>Spry2 mutants</term><term>Spry4</term><term>Spry4 mutants</term><term>Supernumerary</term><term>Supernumerary teeth</term><term>Supernumerary tooth</term><term>Supernumerary tooth development</term><term>Supernumerary tooth formation</term><term>Supernumerary tooth germs</term><term>Tooth</term><term>Tooth development</term><term>Tooth primordia</term><term>Tooth primordium</term><term>Total length</term><term>Viriot</term><term>Vonesch</term><term>Zool</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult mice</term><term>Anterior part</term><term>Anterior portion</term><term>Anteroconid</term><term>Apoptosis</term><term>Apoptotic</term><term>Biol</term><term>Biol peterkova</term><term>Body weight</term><term>Cheek region</term><term>Cobourne</term><term>Craniofac genet</term><term>Cusp</term><term>Cusp pattern</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dental measurements</term><term>Dentition</term><term>Diastema</term><term>Embryo</term><term>Enamel</term><term>Enamel knot</term><term>Enamel organ</term><term>Epithelium</term><term>Evol</term><term>Experimental medicine</term><term>Expression domains</term><term>Histological</term><term>Histological sections</term><term>Horizontal direction</term><term>Incisor</term><term>Jernvall</term><term>Klein</term><term>Larger size</term><term>Leica</term><term>Leica dmlb microscope</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower apoptosis</term><term>Lower molar</term><term>Mandible</term><term>Mitosis</term><term>Mitotic</term><term>Mitotic cells</term><term>Molar</term><term>Morphogenesis</term><term>Morphometric</term><term>Morphometric analysis</term><term>Mouse</term><term>Mouse embryos</term><term>Mouse molar morphogenesis</term><term>Mouse odontogenesis</term><term>Mutant</term><term>Mutant mice</term><term>Odontogenesis</term><term>Ohazama</term><term>Peterka</term><term>Peterkova</term><term>Posteriorly</term><term>Postnatal</term><term>Premolar</term><term>Prenatal</term><term>Prenatal stages</term><term>Present data</term><term>Primordium</term><term>Prochazka</term><term>Quadrant</term><term>Revitalization</term><term>Ruch</term><term>Rudiment</term><term>Rudimentary buds</term><term>Rudimentary tooth primordia</term><term>Rudiments</term><term>Scale bars</term><term>Sonic hedgehog</term><term>Spatial distribution</term><term>Sprouty</term><term>Sprouty genes</term><term>Sprouty mutants</term><term>Spry2</term><term>Spry2 mutants</term><term>Spry4</term><term>Spry4 mutants</term><term>Supernumerary</term><term>Supernumerary teeth</term><term>Supernumerary tooth</term><term>Supernumerary tooth development</term><term>Supernumerary tooth formation</term><term>Supernumerary tooth germs</term><term>Tooth</term><term>Tooth development</term><term>Tooth primordia</term><term>Tooth primordium</term><term>Total length</term><term>Viriot</term><term>Vonesch</term><term>Zool</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2−/− embryos. Apoptosis was also decreased in both rudiments in Spry4−/− embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2−/− mice, a high number of Spry4−/− supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307–320, 2013. © 2013 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Bohême centrale</li><li>Californie</li><li>Grand Est</li></region><settlement><li>Prague</li><li>Strasbourg</li></settlement><orgName><li>Université de Strasbourg</li></orgName></list><tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Lagronova Hurava, Svatava" sort="Lagronova Hurava, Svatava" uniqKey="Lagronova Hurava S" first="Svatava" last="Lagronova-Churava">Svatava Lagronova-Churava</name></region><name sortKey="Lagronova Hurava, Svatava" sort="Lagronova Hurava, Svatava" uniqKey="Lagronova Hurava S" first="Svatava" last="Lagronova-Churava">Svatava Lagronova-Churava</name><name sortKey="Lagronova Hurava, Svatava" sort="Lagronova Hurava, Svatava" uniqKey="Lagronova Hurava S" first="Svatava" last="Lagronova-Churava">Svatava Lagronova-Churava</name><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name><name sortKey="Spoutil, Frantisek" sort="Spoutil, Frantisek" uniqKey="Spoutil F" first="Frantisek" last="Spoutil">Frantisek Spoutil</name><name sortKey="Vojtechova, Simona" sort="Vojtechova, Simona" uniqKey="Vojtechova S" first="Simona" last="Vojtechova">Simona Vojtechova</name></country><country name="France"><region name="Grand Est"><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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